Concept 24 The RNA message is sometimes edited.
Dogma and logic dictated that the mRNA code is a faithful representation of the DNA from which it is transcribed. This exact correspondence between mRNA sequence and DNA sequence was generally upheld in experiments with bacterial cells (prokaryotes).However, inconsistencies surfaced as recombinant-DNA techniques allowed researchers to explore the genes of higher cells (eukaryotes). Then, it was found that mRNA transcripts appeared to be shorter than their corresponding genes. This difference became obvious in electron micrographs of mRNA bound to its complementary DNA template — where regions of DNA without corresponding mRNA form loops.
In fact, the protein coding information in genes is interrupted by non-coding sequences called introns, which results in "split genes." The entire DNA code is faithfully transcribed into a temporary form of RNA (pre-mRNA), but this is edited in the nucleus to yield a mature mRNA. The process of RNA splicing involves removing non-coding regions, introns, and splicing together adjacent coding regions, exons.
DNA and proteins are key molecules of the cell nucleus.
One gene makes one protein.
A gene is made of DNA.
Bacteria and viruses have DNA too.
The DNA molecule is shaped like a twisted ladder.
A half DNA ladder is a template for copying the whole.
RNA is an intermediary between DNA and protein.
DNA words are three letters long.
A gene is a discrete sequence of DNA nucleotides.
The RNA message is sometimes edited.
Some viruses store genetic information in RNA.
RNA was the first genetic molecule.
Mutations are changes in genetic information.
Some types of mutations are automatically repaired.