Concept 41 DNA is only the beginning for understanding the human genome.

Links

Embryo Images

This site has scanning electron micrographs of developing mammalian embryos, mostly mice though there are human embryo pictures. Normal and abnormal development are featured in tutorials based on body parts.

Of Mice and Men

From the Howard Hughes Medical Institute, an article on the how gene targetting works in mice.

Holliday Structure

A brief description with an animated gif of how strand exchange works between two pieces of DNA.

Bibliography

• Capecchi, M.R., 1997, Hox Genes and Mammalian Development, Cold Spring Harbor Symposia on Quantitative Biology, 62: 273-281.
• Capecchi, M.R., 1989, Altering the Genome by Homologous Recombination, Science, 244: 1288-1292.
• Capecchi, M.R., 1994, Targeted Gene Replacement, Scientific American, March, 52-59.
• Davis, A.P., Witte, D.P., Hsieh-Li, H.M., Potter, S.S., and Capecchi, M.R., 1995, Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11, Nature, 375: 791-795.
• Fukushige, S., Sauer, B., 1992, Genomic targeting with a positive-selection lox integration vector allows highly reproducible gene expression in mammalian cells, Proc. Natl. Acad. Sci., 89: 7905-7909.
• Mansour, S.L., Thomas, K.R., Capecchi, M.R., 1988, Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes, Nature, 336: 348-352.
• Sauer, B., Henderson, N., 1988, Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1, Proc. Natl. Acad. Sci., 85: 5166-5170.